Granulosa Cell Production of Anti-Müllerian Hormone Is Increased in Polycystic Ovaries
نویسندگان
چکیده
منابع مشابه
Anti-Müllerian hormone produces endocrine sex reversal of fetal ovaries.
We have previously reported that anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, the testicular glycoprotein involved in regression of the Müllerian ducts of the male fetus, induces the formation of seminiferous cord-like structures in fetal ovaries exposed to it in organ culture. We have now investigated the effect of bovine AMH, purified to homogeneity, on ovarian ...
متن کاملAnti-Müllerian Hormone Recruits BMPR-IA in Immature Granulosa Cells
Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily secreted by the gonads of both sexes. This hormone is primarily known for its role in the regression of the Müllerian ducts in male fetuses. In females, AMH is expressed in granulosa cells of developing follicles. Like other members of the TGF-β superfamily, AMH transduces its signal through two transmembrane serine/threonine kin...
متن کاملAnti-Müllerian hormone in women with polycystic ovary syndrome.
Anti-Müllerian hormone (AMH) is a glycoprotein produced in the granulosa cells of the ovary. It is involved in the regulation of follicular growth and development. AMH serum and follicular fluid concentration is increased in women with polycystic ovary syndrome (PCOS), which correlates with the extent of ovarian dysfunction and clinical manifestation of the syndrome. It is unclear whether the h...
متن کاملIncreased anti-Müllerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome.
CONTEXT Anti-Müllerian hormone (AMH) is produced by the granulosa cells and reflects follicular development. Adult women with polycystic ovary syndrome (PCOS) have increased levels of AMH associated with an excessive number of growing follicles. However, it is not known whether these abnormalities are present before the clinical onset of PCOS. OBJECTIVE Our objective was to investigate whethe...
متن کاملDetermination of serum anti-Müllerian hormone concentrations for the diagnosis of granulosa-cell tumours in mares.
REASONS FOR PERFORMING STUDY Endocrinological assays are important for evaluation of mares with granulosa-cell tumours (GCTs), and our research in mares indicates that anti-Müllerian hormone (AMH) may be a good biomarker for this type of ovarian tumour. OBJECTIVES To evaluate the use of serum AMH concentrations for endocrine diagnosis of GCTs in mares. METHODS Archived serum samples (n = 40...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2007
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2006-1582